bs-2594R [Primary Antibody]
IL1 Receptor I Polyclonal Antibody
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Host: Rabbit

Target Protein: IL-1R1

Immunogen Range: 510-545/569

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3554

Swiss Prot: P14778

Source: KLH conjugated synthetic peptide derived from human IL-1R1

Purification: Purified by Protein A.

Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

Background: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-1000)

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Formalin-fixed and paraffin embedded rat colitis labeled with Anti-IL-1R1/CD121a/IL1 Receptor I Polyclonal Antibody, Unconjugated (bs-2594R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.


L1 rat brain lysates L2 rat kidney lysates probed with Anti IL-1R1/CD121a/IL1 Receptor I Polyclonal Antibody, Unconjugated (bs-2594R) at 1:200 overnight at 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 for 90 min at 37˚C. Predicted band 62kD. Observed band size:62kD.