bs-12421R-A555 [Conjugated Primary Antibody]
14-3-3 gamma Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated
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Host: Rabbit

Target Protein: 14-3-3 gamma

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 7532

Source: KLH conjugated synthetic peptide derived from human 14-3-3 gamma

Purification: Purified by Protein A.

Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.

Background: 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 b, g, e, z, h, q and s. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins; by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity, and facilitation of protein modification. Loss of expression contributes to a vast array of pathogenic cellular activities.

Conjugation: ALEXA FLUOR® 555

Excitation/ Emission: 553nm/568nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.