Target Protein: CD11b, CD11c
Specificity: The immunogen of this product has partial sequence similarity to CD11d and may cross react.
Immunogen Range: 50-100/1152
Entrez Gene: 3684
Swiss Prot: P11215
Source: KLH conjugated synthetic peptide derived from human CD11b
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Background: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.