Target Protein: CIAS1
Immunogen Range: 1-50/1036
Entrez Gene: 114548
Swiss Prot: Q96P20
Source: KLH conjugated synthetic peptide derived from human Cryopyrin
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Background: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.
Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.