Target Protein: CD45
Specificity: The antibody is predicted to work with Mouse and Rat samples, but with decreased sensitivity compared to human samples.
Immunogen Range: 1210-1260/1306
Entrez Gene: 5788
Swiss Prot: P08575
Source: KLH conjugated synthetic peptide derived from human CD45
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Background: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Cross Reactive Species: Human
For research use only. Not intended for diagnostic or therapeutic use.