Target Protein: 14-3-3 Alpha + Beta + Gamma + Delta + Epsilon
Immunogen Range: 200-246/246
Entrez Gene: 7529
Swiss Prot: P31946
Source: KLH conjugated synthetic peptide derived from human 14-3-3
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Background: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.
Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.