Target Protein: Caspase-9
Immunogen Range: 280-330/416
Entrez Gene: 842
Swiss Prot: P55211
Source: KLH conjugated synthetic peptide derived from human Caspase-9 subunit p35
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store at 4°C for 12 months.
Background: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Cross Reactive Species: Human
For research use only. Not intended for diagnostic or therapeutic use.